16 September 2022
17:30	Benetton	v	Glasgow Warriors
19:35	Cardiff	v	Munster

17 September 2022
13:00	Zebre Parma	v	Leinster
15:05	Lions	v	Bulls
17:15	Scarlets	v	Ospreys
19:35	Edinburgh	v	Dragons
19:35	Ulster	v	Connacht

23 September 2022
17:30	Zebre Parma	v	Sharks
19:35	Glasgow Warriors	v	Cardiff
19:35	Leinster	v	Benetton

24 September 2022
13:00	Scarlets	v	Ulster
14:30	Bulls	v	Edinburgh
16:45	Stormers	v	Connacht
19:35	Ospreys	v	Lions

25 September 2022
15:00	Dragons	v	Munster

30 September 2022
17:30	Bulls	v	Connacht
19:35	Cardiff	v	Lions
19:35	Ulster	v	Leinster

1 October 2022
13:00	Stormers	v	Edinburgh
15:05	Ospreys	v	Glasgow Warriors
17:05	Munster	v	Zebre Parma
17:15	Benetton	v	Scarlets
19:35	Dragons	v	Sharks

7 October 2022
19:35	Connacht	v	Munster
19:35	Edinburgh	v	Lions

8 October 2022
15:00	Zebre Parma	v	Stormers
17:05	Leinster	v	Sharks
17:15	Scarlets	v	Cardiff
19:35	Glasgow Warriors	v	Bulls
19:35	Ulster	v	Ospreys

9 October 2022
14:45	Benetton	v	Dragons

14 October 2022
19:35	Connacht	v	Leinster
19:35	Ospreys	v	Stormers

15 October 2022
13:00	Lions	v	Ulster
15:05	Sharks	v	Glasgow Warriors
17:15	Cardiff	v	Dragons
17:15	Edinburgh	v	Benetton
19:35	Munster	v	Bulls
19:35	Scarlets	v	Zebre Parma

21 October 2022
17:30	Benetton	v	Bulls
19:35	Connacht	v	Scarlets

22 October 2022
13:00	Zebre Parma	v	Edinburgh
15:05	Lions	v	Glasgow Warriors
17:15	Sharks	v	Ulster
19:35	Cardiff	v	Stormers
19:35	Leinster	v	Munster

23 October 2022
15:00	Dragons	v	Ospreys

28 October 2022
19:35	Glasgow Warriors	v	Benetton
19:35	Scarlets	v	Leinster

29 October 2022
15:00	Lions	v	Stormers
17:15	Dragons	v	Zebre Parma
17:15	Munster	v	Ulster
19:35	Ospreys	v	Connacht

30 October 2022
15:00	Cardiff	v	Edinburgh

25 November 2022
17:00	Stormers	v	Scarlets
19:35	Ulster	v	Zebre Parma

26 November 2022
13:00	Benetton	v	Edinburgh
13:00	Bulls	v	Ospreys
15:15	Leinster	v	Glasgow Warriors
19:35	Munster	v	Connacht

27 November 2022
14:00	Lions	v	Dragons
16:10	Sharks	v	Cardiff

2 December 2022
17:00	Sharks	v	Ospreys
19:35	Edinburgh	v	Munster

3 December 2022
12:00	Stormers	v	Dragons
13:00	Zebre Parma	v	Glasgow Warriors
15:15	Connacht	v	Benetton
18:00	Bulls	v	Cardiff
19:35	Leinster	v	Ulster

4 December 2022
11:30	Lions	v	Scarlets

23 December 2022
15:00	Sharks	v	Lions
17:15	Stormers	v	Bulls
19:35	Connacht	v	Ulster
19:35	Glasgow Warriors	v	Edinburgh

24 December 2022
12:30	Benetton	v	Zebre Parma

26 December 2022
14:15	Dragons	v	Cardiff
17:15	Ospreys	v	Scarlets
19:35	Munster	v	Leinster

30 December 2022
19:35	Edinburgh	v	Glasgow Warriors

31 December 2022
12:30	Zebre Parma	v	Benetton
14:45	Sharks	v	Bulls
17:00	Stormers	v	Lions

1 January 2023
15:00	Cardiff	v	Ospreys
17:15	Scarlets	v	Dragons
17:15	Ulster	v	Munster
19:35	Leinster	v	Connacht

6 January 2023
19:35	Dragons	v	Bulls
19:35	Munster	v	Lions

7 January 2023
13:00	Benetton	v	Ulster
15:00	Edinburgh	v	Zebre Parma
17:15	Cardiff	v	Scarlets
17:15	Connacht	v	Sharks
19:35	Ospreys	v	Leinster

8 January 2023
15:00	Glasgow Warriors	v	Stormers

27 January 2023
19:35	Scarlets	v	Bulls
19:35	Ulster	v	Stormers

28 January 2023
14:30	Benetton	v	Munster
15:00	Dragons	v	Glasgow Warriors
17:00	Leinster	v	Cardiff
17:15	Edinburgh	v	Sharks
19:35	Connacht	v	Lions

29 January 2023
15:00	Zebre Parma	v	Ospreys

3 February 2023
17:00	Sharks	v	Stormers

10 February 2023
17:00	Bulls	v	Sharks

17 February 2023
19:35	Glasgow Warriors	v	Ulster
19:35	Munster	v	Ospreys

18 February 2023
13:00	Lions	v	Sharks
15:05	Bulls	v	Stormers
15:05	Zebre Parma	v	Connacht
17:15	Cardiff	v	Benetton
17:15	Scarlets	v	Edinburgh
19:35	Leinster	v	Dragons

3 March 2023
19:35	Glasgow Warriors	v	Zebre Parma
19:35	Munster	v	Scarlets

4 March 2023
12:30	Stormers	v	Sharks
14:45	Bulls	v	Lions
17:05	Edinburgh	v	Leinster
17:15	Ospreys	v	Benetton
19:35	Cardiff	v	Ulster
19:35	Dragons	v	Connacht

24 March 2023
19:10	Zebre Parma	v	Cardiff
19:35	Leinster	v	Stormers

25 March 2023
13:00	Benetton	v	Lions
15:00	Ospreys	v	Dragons
15:05	Connacht	v	Edinburgh
17:15	Munster	v	Glasgow Warriors
19:35	Scarlets	v	Sharks
19:35	Ulster	v	Bulls

14 April 2023
17:30	Sharks	v	Benetton
19:35	Glasgow Warriors	v	Scarlets
19:35	Ulster	v	Dragons

15 April 2023
13:00	Lions	v	Leinster
15:05	Bulls	v	Zebre Parma
17:15	Stormers	v	Munster
19:35	Connacht	v	Cardiff
19:35	Edinburgh	v	Ospreys

21 April 2023
17:30	Stormers	v	Benetton
19:35	Ulster	v	Edinburgh

22 April 2023
13:00	Lions	v	Zebre Parma
15:00	Dragons	v	Scarlets
15:05	Bulls	v	Leinster
17:15	Ospreys	v	Cardiff
17:15	Sharks	v	Munster
19:35	Glasgow Warriors	v	Connacht