11 December 2020
17:30	Stade Francais	v	Benetton
19:45	Leicester	v	Brive
20:00	Newcastle	v	Cardiff Blues

12 December 2020
13:00	Zebre	v	Bayonne
14:00	Agen	v	London Irish
20:00	Ospreys	v	Castres
20:00	Pau	v	Worcester

18 December 2020
17:30	Castres	v	Newcastle
20:00	Brive	v	Zebre

19 December 2020
13:00	Benetton	v	Agen
20:00	Bayonne	v	Leicester
20:00	Worcester	v	Ospreys

20 December 2020
15:00	London Irish	v	Pau
17:30	Cardiff Blues	v	Stade Francais

15 January 2021
17:30	Pau	v	London Irish
19:45	Leicester	v	Bayonne
20:00	Agen	v	Benetton
20:00	Ospreys	v	Worcester

16 January 2021
13:00	Zebre	v	Brive
15:00	Newcastle	v	Castres
20:00	Stade Francais	v	Cardiff Blues

22 January 2021
14:30	Brive	v	Leicester
tbc
14:30	Castres	v	Ospreys
tbc
20:00	Bayonne	v	Zebre

23 January 2021
13:00	Benetton	v	Stade Francais
15:00	London Irish	v	Agen
15:00	Worcester	v	Pau
20:00	Cardiff Blues	v	Newcastle