13 November 2021
Abergele		v	Bangor
Colwyn Bay		v	Mold
Nant Conwy II		v	Newtown
Rhyl & District		v	Shotton Steel
Welshpool		v	Wrexham

27 November 2021
Bangor		v	Rhyl & District
Mold		v	Abergele
Newtown		v	Welshpool
Shotton Steel		v	Nant Conwy II
Wrexham		v	Colwyn Bay

4 December 2021
Abergele		v	Wrexham
Colwyn Bay		v	Welshpool
Nant Conwy II		v	Bangor
Rhyl & District		v	Mold
Shotton Steel		v	Newtown

18 December 2021
Bangor		v	Shotton Steel
Mold		v	Nant Conwy II
Newtown		v	Colwyn Bay
Welshpool		v	Abergele
Wrexham		v	Rhyl & District

8 January 2022
Abergele		v	Colwyn Bay
Bangor		v	Newtown
Nant Conwy II		v	Wrexham
Rhyl & District		v	Welshpool
Shotton Steel		v	Mold

15 January 2022
Colwyn Bay		v	Rhyl & District
Mold		v	Bangor
Newtown		v	Abergele
Welshpool		v	Nant Conwy II
Wrexham		v	Shotton Steel

29 January 2022
Bangor		v	Wrexham
Mold		v	Newtown
Nant Conwy II		v	Colwyn Bay
Rhyl & District		v	Abergele
Shotton Steel		v	Welshpool

19 February 2022
Abergele		v	Nant Conwy II
Colwyn Bay		v	Shotton Steel
Newtown		v	Rhyl & District
Welshpool		v	Bangor
Wrexham		v	Mold

5 March 2022
Bangor		v	Colwyn Bay
Mold		v	Welshpool
Nant Conwy II		v	Rhyl & District
Shotton Steel		v	Abergele
Wrexham		v	Newtown