13 November 2021
Felinfoel		v	Penclawdd
Gowerton		v	Newcastle Emlyn
Llangennech		v	Llanelli Wanderers
Pembroke		v	Gorseinon
Whitland		v	Crymych
Yr Hendy		v	Aberystwyth

27 November 2021
Aberystwyth		v	Whitland
Crymych		v	Pembroke
Gorseinon		v	Llangennech
Llanelli Wanderers		v	Gowerton
Newcastle Emlyn		v	Felinfoel
Penclawdd		v	Yr Hendy

4 December 2021
Felinfoel		v	Llanelli Wanderers
Gowerton		v	Gorseinon
Llangennech		v	Crymych
Pembroke		v	Whitland
Penclawdd		v	Aberystwyth
Yr Hendy		v	Newcastle Emlyn

11 December 2021
Aberystwyth		v	Pembroke
Crymych		v	Gowerton
Gorseinon		v	Felinfoel
Llanelli Wanderers		v	Yr Hendy
Newcastle Emlyn		v	Penclawdd
Whitland		v	Llangennech

18 December 2021
Felinfoel		v	Crymych
Gowerton		v	Whitland
Llangennech		v	Pembroke
Newcastle Emlyn		v	Aberystwyth
Penclawdd		v	Llanelli Wanderers
Yr Hendy		v	Gorseinon

8 January 2022
Aberystwyth		v	Llangennech
Crymych		v	Yr Hendy
Gorseinon		v	Penclawdd
Llanelli Wanderers		v	Newcastle Emlyn
Pembroke		v	Gowerton
Whitland		v	Felinfoel

15 January 2022
Felinfoel		v	Pembroke
Gowerton		v	Llangennech
Llanelli Wanderers		v	Aberystwyth
Newcastle Emlyn		v	Gorseinon
Penclawdd		v	Crymych
Yr Hendy		v	Whitland

29 January 2022
Aberystwyth		v	Gowerton
Crymych		v	Newcastle Emlyn
Gorseinon		v	Llanelli Wanderers
Llangennech		v	Felinfoel
Pembroke		v	Yr Hendy
Whitland		v	Penclawdd

19 February 2022
Felinfoel		v	Gowerton
Gorseinon		v	Aberystwyth
Llanelli Wanderers		v	Crymych
Newcastle Emlyn		v	Whitland
Penclawdd		v	Pembroke
Yr Hendy		v	Llangennech

5 March 2022
Crymych		v	Gorseinon
Felinfoel		v	Aberystwyth
Gowerton		v	Yr Hendy
Llangennech		v	Penclawdd
Pembroke		v	Newcastle Emlyn
Whitland		v	Llanelli Wanderers

12 March 2022
Aberystwyth		v	Crymych
Gorseinon		v	Whitland
Llanelli Wanderers		v	Pembroke
Newcastle Emlyn		v	Llangennech
Penclawdd		v	Gowerton
Yr Hendy		v	Felinfoel