3 October 2021
Round 3
Aberdare Town		v	Garw SBGC
Barry Town United		v	Aberystwyth Town
Briton Ferry Llansawel		v	Llanelli Town
Buckley Town		v	Flint Town United
Caerau Ely		v	Taffs Well
Cefn Druids		v	The New Saints
Penybont		v	Cardiff Met Univ
Wrexham		v	Caernarfon Town

12 September 2021
Round 2
Aberdare Town	3	1	Ynysygerwn
Aberystwyth Town	2	2	Cambrian & Clydach
Aberystwyth Town won 5-3 on pens.
Airbus UK Broughton	1	1	Buckley Town
Buckley Town won 4-3 on pens.
Barry Town United	3	2	Mumbles Rangers
Briton Ferry Llansawel	6	3	Newport County
Carmarthen Town	3	4	Taffs Well
Cefn Druids	5	1	Llandudno
Flint Town United	6	2	Brickfield Rangers
Garw SBGC	15	2	AC Pontymister
Pentyrch Rangers	0	4	Llanelli Town
Penybont	4	0	Ammanford
Rhydyfelin	1	3	Caerau Ely

22 August 2021
Round 1
Aberdare Town	1	3	Cwmbran Celtic
Ammanford	3	1	Trefelin BGC
Brickfield Rangers	3	2	Bangor City
Caerau Ely	4	2	Merthyr Saints
Caernarfon Town	10	0	Rhydymwyn
Cambrian & Clydach	3	0	Tredegar Town
Carmarthen Town	7	0	West End
Colwyn Bay	1	2	Airbus UK Broughton
Haverfordwest County	0	5	Briton Ferry Llansawel
Llandudno	4	3	Brymbo Lodge
Llantwit Major	1	3	Llanelli Town
Penybont	8	0	Pontardawe Town
Rhydyfelin	4	0	Ely Rangers
Risca United	1	1	Taffs Well
Taffs Well won 9-8 on pens.
Ruthin Town	1	13	Wrexham

20 August 2021
Round 1
Connahs Quay Nomads	5	0	Buckley Town

8 August 2021
Preliminary Round
CKSV	1	6	Garw SBGC
Ely Rangers	3	0	Canton Liberal
Pentwynmawr Athletic	1	2	Tredegar Town
Rhos Aelwyd	3	3	Rhydymwyn
Rhydymwyn won 5-4 on pens.