19 January 2022
Round 1
Aberaeron		v	Q E High School
Cardiff High School		v	Bassaleg
Maes y Gwendraeth		v	Bro Dinefwr
Ysgol y Strade		v	Penweddig

26 January 2022
Round 1
Bro Morgannwg		v	Llangynwyd
Dyffryn Taf		v	Ysgol Greenhill
Gwyr		v	Haverfordwest HS
Llandovery College		v	Ysgol Preseli
Treorchy		v	Bryntirion
Ysgol Dyffryn Aman		v	Coleg Sir Gâr II

19 January 2022
Round 1
Bishop of Llandaff	10	64	Christ College Brecon
Bro Edern	10	29	Llanishen
Bro Myrddin	12	36	Ysgol Ystalyfera
Coleg y Dderwen	17	19	Porthcawl
Penybont	12	20	Plasmawr
Stanwell	20	21	Brynteg