3 September 2022
Aberavon		v	Bridgend
Carmarthen Quins		v	Llandovery
Llanelli		v	Swansea
Merthyr		v	RGC
Newport		v	Ebbw Vale
Pontypridd		v	Cardiff

8 September 2022
Swansea		v	Aberavon
7.30pm

10 September 2022
Bridgend		v	Carmarthen Quins
Cardiff		v	Merthyr
Ebbw Vale		v	Llanelli
Llandovery		v	Pontypridd
RGC		v	Newport
5.30pm

24 September 2022
Aberavon		v	Llanelli
Carmarthen Quins		v	Swansea
Ebbw Vale		v	RGC
Merthyr		v	Llandovery
Newport		v	Cardiff
Pontypridd		v	Bridgend

1 October 2022
Aberavon		v	Carmarthen Quins
Bridgend		v	Merthyr
Cardiff		v	Ebbw Vale
Llandovery		v	Newport
Llanelli		v	RGC
Swansea		v	Pontypridd

6 October 2022
Ebbw Vale		v	Llandovery
7.30pm

8 October 2022
Carmarthen Quins		v	Llanelli
Merthyr		v	Swansea
Newport		v	Bridgend
Pontypridd		v	Aberavon
RGC		v	Cardiff

15 October 2022
Aberavon		v	Merthyr
Bridgend		v	Ebbw Vale
Carmarthen Quins		v	Pontypridd
Llandovery		v	RGC
Llanelli		v	Cardiff
Swansea		v	Newport

29 October 2022
Cardiff		v	Llandovery
Ebbw Vale		v	Swansea
Merthyr		v	Carmarthen Quins
Newport		v	Aberavon
Pontypridd		v	Llanelli
RGC		v	Bridgend

12 November 2022
Aberavon		v	Ebbw Vale
Bridgend		v	Cardiff
Carmarthen Quins		v	Newport
Llanelli		v	Llandovery
Pontypridd		v	Merthyr
Swansea		v	RGC

18 November 2022
Cardiff		v	Swansea
Ebbw Vale		v	Carmarthen Quins
Llandovery		v	Bridgend
Merthyr		v	Llanelli
Newport		v	Pontypridd
RGC		v	Aberavon

10 December 2022
Aberavon		v	Cardiff
Carmarthen Quins		v	RGC
Llanelli		v	Bridgend
Merthyr		v	Newport
Pontypridd		v	Ebbw Vale
Swansea		v	Llandovery

17 December 2022
Bridgend		v	Swansea
Cardiff		v	Carmarthen Quins
Ebbw Vale		v	Merthyr
Llandovery		v	Aberavon
Newport		v	Llanelli
RGC		v	Pontypridd

26 December 2022
Bridgend		v	Aberavon
Cardiff		v	Pontypridd
Ebbw Vale		v	Newport
Llandovery		v	Carmarthen Quins
RGC		v	Merthyr
Swansea		v	Llanelli

7 January 2023
Aberavon		v	Swansea
Carmarthen Quins		v	Bridgend
Llanelli		v	Ebbw Vale
Merthyr		v	Cardiff
Newport		v	RGC
Pontypridd		v	Llandovery

14 January 2023
Bridgend		v	Pontypridd
Cardiff		v	Newport
Llandovery		v	Merthyr
Llanelli		v	Aberavon
RGC		v	Ebbw Vale
Swansea		v	Carmarthen Quins

21 January 2023
Carmarthen Quins		v	Aberavon
Ebbw Vale		v	Cardiff
Merthyr		v	Bridgend
Newport		v	Llandovery
Pontypridd		v	Swansea
RGC		v	Llanelli

28 January 2023
Aberavon		v	Pontypridd
Bridgend		v	Newport
Cardiff		v	RGC
Llandovery		v	Ebbw Vale
Llanelli		v	Carmarthen Quins
Swansea		v	Merthyr

18 February 2023
Cardiff		v	Llanelli
Ebbw Vale		v	Bridgend
Merthyr		v	Aberavon
Newport		v	Swansea
Pontypridd		v	Carmarthen Quins
RGC		v	Llandovery

4 March 2023
Aberavon		v	Newport
Bridgend		v	RGC
Carmarthen Quins		v	Merthyr
Llandovery		v	Cardiff
Llanelli		v	Pontypridd
Swansea		v	Ebbw Vale

25 March 2023
Cardiff		v	Bridgend
Ebbw Vale		v	Aberavon
Llandovery		v	Llanelli
Merthyr		v	Pontypridd
Newport		v	Carmarthen Quins
RGC		v	Swansea

1 April 2023
Aberavon		v	RGC
Bridgend		v	Llandovery
Carmarthen Quins		v	Ebbw Vale
Llanelli		v	Merthyr
Pontypridd		v	Newport
Swansea		v	Cardiff

8 April 2023
Bridgend		v	Llanelli
Cardiff		v	Aberavon
Ebbw Vale		v	Pontypridd
Llandovery		v	Swansea
Newport		v	Merthyr
RGC		v	Carmarthen Quins

15 April 2023
Aberavon		v	Llandovery
Carmarthen Quins		v	Cardiff
Llanelli		v	Newport
Merthyr		v	Ebbw Vale
Pontypridd		v	RGC
Swansea		v	Bridgend