13 November 2021
Brecon		v	Pontypool United
Dowlais		v	Newbridge
Nelson		v	Monmouth
Penallta		v	Brynmawr
Risca		v	Blaenavon
Senghenydd		v	Bedlinog

27 November 2021
Bedlinog		v	Risca
Blaenavon		v	Penallta
Brynmawr		v	Nelson
Monmouth		v	Dowlais
Newbridge		v	Brecon
Pontypool United		v	Senghenydd

4 December 2021
Brecon		v	Monmouth
Dowlais		v	Brynmawr
Nelson		v	Blaenavon
Penallta		v	Risca
Pontypool United		v	Bedlinog
Senghenydd		v	Newbridge

11 December 2021
Bedlinog		v	Penallta
Blaenavon		v	Dowlais
Brynmawr		v	Brecon
Monmouth		v	Senghenydd
Newbridge		v	Pontypool United
Risca		v	Nelson

18 December 2021
Brecon		v	Blaenavon
Dowlais		v	Risca
Nelson		v	Penallta
Newbridge		v	Bedlinog
Pontypool United		v	Monmouth
Senghenydd		v	Brynmawr

8 January 2022
Bedlinog		v	Nelson
Blaenavon		v	Senghenydd
Brynmawr		v	Pontypool United
Monmouth		v	Newbridge
Penallta		v	Dowlais
Risca		v	Brecon

15 January 2022
Brecon		v	Penallta
Dowlais		v	Nelson
Monmouth		v	Bedlinog
Newbridge		v	Brynmawr
Pontypool United		v	Blaenavon
Senghenydd		v	Risca

29 January 2022
Bedlinog		v	Dowlais
Blaenavon		v	Newbridge
Brynmawr		v	Monmouth
Nelson		v	Brecon
Penallta		v	Senghenydd
Risca		v	Pontypool United

19 February 2022
Brecon		v	Dowlais
Brynmawr		v	Bedlinog
Monmouth		v	Blaenavon
Newbridge		v	Risca
Pontypool United		v	Penallta
Senghenydd		v	Nelson

5 March 2022
Blaenavon		v	Brynmawr
Brecon		v	Bedlinog
Dowlais		v	Senghenydd
Nelson		v	Pontypool United
Penallta		v	Newbridge
Risca		v	Monmouth

12 March 2022
Bedlinog		v	Blaenavon
Brynmawr		v	Risca
Monmouth		v	Penallta
Newbridge		v	Nelson
Pontypool United		v	Dowlais
Senghenydd		v	Brecon